The Human Genome Sequencing Consortium published an update on the whole
genome sequence of Homo Sapiens in 2004 and concluded that there are between
20,000 and 25,000 structural genes. This is lower than the lowest estimate
of the gene sweepstake given as 27,462 and is lower
than the 2001 estimated number of 35,000 genes when the first draft sequence
of the human genome was published. (Reference: Human Genome Sequencing
Consortium, I. (2004). "Finishing the euchromatic sequence of the
human genome." Nature 431(7011): 931-945.)
UPDATE: 'The Human Genome 2012: 18,451 RNA genes, 11,224 pseudogenes, 20,687 protein coding genes, an average of 6.3 splice variants per gene, gene sequences cover 2.94% of the genome, exon sequences cover 1.22% of the genome' (ENCODE, Nature.com)
Once upon a time ...
before the completion of the human genome project:
Gene Sweepstake Once you
know what a gene is, bet your money on it!
The figure shows the status of bets as of August 2002.
The Gene Sweepstake was run between 2000 and 2003. The rules were: It
costs $1 to make a bet in 2000, $5 in 2001 and $20 in 2002. Bets
are for one number. Closest number wins, and in case of ties, the pot
is split. Bets are based on the following definition: a gene is a set
of connected transcripts. A transcript is a set of exons via transcription
followed (optionally) by pre-mRNA splicing. Two transcripts are connected
if they share at least part of one exon in the genomic coordinates. At
least one transcript must be expressed outside of the nucleus and one
transcript must encode a protein.
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Copyright © 2000-2012 Lukas