Images of Biological Macro-Molecules


Structures of Peptides and Proteins

Globular Proteins
Brazzein, NMR structure (1BRZ)
Brazzein, energy minimized from NMR (2BRZ)
Calmodulin (1CLM)
Carbonic Anhydrase
(1CAH)
Cellulase (1CEC)
Cytochrome (1HRC)

Hemoglobin
deoxy or T-state (1HGA)
Hemoglobin HbS, sickle cell (1HDS)

Histone octamer complex (1HIO)

HIV Reverse Transcriptase (1REV)
HIV Protease with tripeptide inhibitor (1A30)

Nucleosome core particel (1AOI)
N-cadherin (1NCH)

Myoglobin, deoxy, without oxygen (1MBN)
Myoglobin, oxy, with oxygen (1MBO)

Pyruvate Kinase, E.coli (1PKY)
Subtilisin  (serine protease with inhibitor eglin) (1CSE)
TATA Box Binding Protein (1YTB)

TFIID TBP associated factor (1TAF)

Trypsin (1BRB; variant) with BPTI (variant)

Membrane Proteins
Beta-2 Adrenergic Receptor (GPCR)
   - with antibody fragment (24R4)
   - with lysozyme domain (2RH1)
Bacteriorhodopsin (1AP9)

   - by X-ray (1AP9)

   - by electron diffraction (1AT9)

Bovine Rhosdopsin (1F88)

Ca-ATPase (P-type; muscle SR; 1EUL)
G-protein coupled receptor   (model)
Gap Junction Protein
Beta2 hemi-channel (Connexin 26; 2ZW3)
Porin
non specific; single subunit of OmpF (1PRN)
Porin maltose specific (1MAL); with maltose (1AF6)

K-channel Kcsa (1BL8)
Light harvesting complex 2 (1KZU)
Reaction center(1PRC)


A complete list of known structures of membrane proteins at the Stephen White laboratory at UC Irvine

Structures of Nucleic Acids, Polysaccharides, and Lipids

IMPORTANT NOTICE: The following is a list of molecules from the Protein Data Bank. You will need Chime installed in your browser or use Rasmol as a stand-alone program on your computer to view these images after downloading the pdb files. 

Nucleic Acids
Deoxy-Ribonucleic Acid
(114D)
A-RNA
(1SDR)
Transfer RNA
(1TN2; yest Phe-tRNA)
Anticodon loop
(229D)
tRNA-synthetase complex (1GTR)

Polysaccharides
Hyaluronic acid

Disaccharides (KEGG)

Polysaccharides (KEGG)

Lipids
Plasma Membrane

POPC - Palmitoyl-oleoyl-phosphatidyl-choline 

(view list of phospholipids at KEGG)

DHPC - Diheptanoyl-phosphatidyl-choline (detergent cmc 1.4mM; after opening file select 3D rendering)

Cholesterol

11-cis-retinal

Channel-forming Peptides
Gramicidin A
(dimer; 1MAG)
     Molecular dynamics simulation

     Channel recording in artifical membrane

     (you need QuickTime3 to view movie)

Alamethicin (1MLT; trimer shown; forms multimers)


Links to databases with access to structures of biological molecules
PDB Protein Data Bank Tools and resources for studying the structures of biological macromolecules
NCBI National Center for Biotechnology Information Resource for molecular biology information, sequences, structures and whole genome maps
KEGG Kyoto Encyclopedia of Genes and Genomes Metabolic pathway maps and molecular catalogue
RNA Database RNA modification database Post-transcriptionally modified nucleosides from RNA

Please send any questions or comments regarding this class to Lukas Buehler

H o m e
 Copyright © 2000-2010 Lukas K. Buehler